After setting up my account I had a hard time starting to use FF. One of the big issues for me was: who is on FF and who is on Twitter? And how do I import all my Twitter friends to FF, without duplicating? This basically is too difficult for most users, I think. I used the 'Twitter2FF' tool, which helps. I ended up writing down lists on paper to make sure I didn't duplicate and really have all my Twitter friend in FF.
Furthermore some Twitter friends have protected their account. These can't be imported to FF. This is one of the reasons I still use Tweetdeck. The other reason I check Tweetdeck is for retweeting. And I also use Tweetdeck when I 'live tweet' an event. I don't find Friendfeed good enough for real-time, although the new FF has solved this issue I think. I hope to try live-tweeting using FF soon.
I've heard that some also import all their RSS feeds in FF. I don't. I still read my feeds with Google Reader. For all other stuff I use Friendfeed.
I really enjoy having one stream of updates to watch. With the new Friendfeed the stream is even in real-time by default.
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Loving FriendFeed http://twurl.nl/mf4fgq